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CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience

Affiliations

  • 1 Pediatric Neurology Units of Chaim Sheba Medical Center, Tel Hashomer. Electronic address: [email protected]
  • 2 Pediatric Neurology Units of Tel Aviv Sourasky Medical Center, Tel Aviv.
  • 3 Pediatric Neurology Units of Wolfson Medical Center, Holon.
  • 4 Pediatric Neurology Units of Assaf Harofeh Medical Center, Zrifin.
  • 5 Pediatric Neurology Units of Chaim Sheba Medical Center, Tel Hashomer.
  • 6 Pediatric Neurology Units of Panaxia Medical Devices and Pharmaceuticals, Tel Aviv, Israel.
  • 7 Pediatric Neurology Units of Medical Cannabis Unit, Ministry of Health, Tel Aviv, Israel.
  • PMID: 26800377
  • DOI: 10.1016/j.seizure.2016.01.004

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CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience

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Authors

Affiliations

  • 1 Pediatric Neurology Units of Chaim Sheba Medical Center, Tel Hashomer. Electronic address: [email protected]
  • 2 Pediatric Neurology Units of Tel Aviv Sourasky Medical Center, Tel Aviv.
  • 3 Pediatric Neurology Units of Wolfson Medical Center, Holon.
  • 4 Pediatric Neurology Units of Assaf Harofeh Medical Center, Zrifin.
  • 5 Pediatric Neurology Units of Chaim Sheba Medical Center, Tel Hashomer.
  • 6 Pediatric Neurology Units of Panaxia Medical Devices and Pharmaceuticals, Tel Aviv, Israel.
  • 7 Pediatric Neurology Units of Medical Cannabis Unit, Ministry of Health, Tel Aviv, Israel.
  • PMID: 26800377
  • DOI: 10.1016/j.seizure.2016.01.004

Abstract

Purpose: To describe the experience of five Israeli pediatric epilepsy clinics treating children and adolescents diagnosed as having intractable epilepsy with a regimen of medical cannabis oil.

Methods: A retrospective study describing the effect of cannabidiol (CBD)-enriched medical cannabis on children with epilepsy. The cohort included 74 patients (age range 1-18 years) with intractable epilepsy resistant to >7 antiepileptic drugs. Forty-nine (66%) also failed a ketogenic diet, vagal nerve stimulator implantation, or both. They all started medical cannabis oil treatment between 2-11/2014 and were treated for at least 3 months (average 6 months). The selected formula contained CBD and tetrahydrocannabinol at a ratio of 20:1 dissolved in olive oil. The CBD dose ranged from 1 to 20mg/kg/d. Seizure frequency was assessed by parental report during clinical visits.

Results: CBD treatment yielded a significant positive effect on seizure load. Most of the children (66/74, 89%) reported reduction in seizure frequency: 13 (18%) reported 75-100% reduction, 25 (34%) reported 50-75% reduction, 9 (12%) reported 25-50% reduction, and 19 (26%) reported Conclusions: The results of this multicenter study on CBD treatment for intractable epilepsy in a population of children and adolescents are highly promising. Further prospective, well-designed clinical trials using enriched CBD medical cannabis are warranted.

Keywords: CBD-enriched medical cannabis; Intractable epilepsy.

Copyright © 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

The results of this multicenter study on CBD treatment for intractable epilepsy in a population of children and adolescents are highly promising. Further prospective, well-designed clinical trials using enriched CBD medical cannabis are warranted.