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cbd dosage for seizures

cannabidiol (Rx)

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Dosing & Uses

Dosage Forms & Strengths

solution, oral
  • 100mg/mL

Seizures

Indicated for seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), or tuberous sclerosis complex (TSC)

LGS or DS
  • 2.5 mg/kg PO BID initially; after 1 week, may increase to maintenance dose of 5 mg/kg BID
  • If 5 mg/kg BID tolerated and further seizure reduction required, patient may benefit from a dosage increase up to a maximum recommended maintenance dosage of 10 mg/kg BID (ie, 20 mg/kg/day)
  • Increasing to 10 mg/kg BID may be achieved by increased weekly increments of 2.5 mg/kg BID, as tolerated
  • If a more rapid titration from 10 mg/kg/day to 20 mg/kg/day is warranted, the dosage may be increased no more frequently than every other day
  • Administration of the 20-mg/kg/day dosage resulted in somewhat greater reductions in seizure rates than the recommended maintenance dosage of 10 mg/kg/day, but with an increase in adverse reactions
  • Starting dose: 2.5 mg/kg PO BID
  • Increase dose in weekly increments of 2.5 mg/kg BID as tolerated, to recommended maintenance dose of 12.5 mg/kg BID
  • If a more rapid titration is warranted, the dosage may be increased no more frequently than every other day
  • Effectiveness of doses 3 x ULN in presence of elevated bilirubin without alternative explanation are important predictors of severe liver injury and should be evaluated before initiating cannabidiol

Hepatitis (Orphan)

Orphan designation for treatment of autoimmune hepatitis

Orphan sponsor
  • Revive Therapeutics Ltd; 5 Director Court, Suite 105; Vaughan, Ontario; Canada

Huntington Disease (Orphan)

Orphan designation for delta-9-THC and cannabidiol for treatment of Huntington disease

Sponsor
  • MMJ International Holdings; 1895 Preston White Drive, Suite 101; Reston, Virginia 20191

Dosage Forms & Strengths

solution, oral
  • 100mg/mL

Seizures

Indicated for seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), or tuberous sclerosis complex (TSC) in patients aged ≥1 yr

Age ≥1 year
LGS or DS
  • 2.5 mg/kg PO BID initially; after 1 week, may increase to maintenance dose of 5 mg/kg BID
  • If 5 mg/kg BID tolerated and further seizure reduction required, patient may benefit from a dosage increase up to a maximum recommended maintenance dosage of 10 mg/kg BID (ie, 20 mg/kg/day)
  • Increasing to 10 mg/kg BID may be achieved by increased weekly increments of 2.5 mg/kg BID, as tolerated
  • If a more rapid titration from 10 mg/kg/day to 20 mg/kg/day is warranted, the dosage may be increased no more frequently than every other day
  • Administration of the 20-mg/kg/day dosage resulted in somewhat greater reductions in seizure rates than the recommended maintenance dosage of 10 mg/kg/day, but with an increase in adverse reactions
    • Starting dose: 2.5 mg/kg PO BID
    • Increase dose in weekly increments of 2.5 mg/kg BID as tolerated, to recommended maintenance dose of 12.5 mg/kg BID
    • If a more rapid titration is warranted, the dosage may be increased no more frequently than every other day
    • Effectiveness of doses 3 x ULN in presence of elevated bilirubin without alternative explanation are important predictors of severe liver injury and should be evaluated before initiating cannabidiol

    Absence Epilepsy (Orphan)

    Orphan designation for treatment of childhood absence epilepsy

    Orphan sponsor
    • Insys Development Company, Inc; 1333 South Spectrum Blvd, Suite 100; Chandler, Arizona 85286

    Clinical trials did not include any patients aged >55 yr to determine whether or not they respond differently from younger patients

    In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy

    Interactions

    Interaction Checker
    Contraindicated
    Serious – Use Alternative
    Significant – Monitor Closely
    Minor

    Adverse Effects

    >10% (LGS or DS)

    Infections, all (40-41%)

    Infection, other (21-25%)

    Decreased appetite (16-22%)

    Transaminases elevated (8-16%)

    Fatigue, malaise, asthenia (11-12%)

    Infection, viral (7-11%)

    >10% (TSC)

    Elevated transaminases (25%)

    Decreased appetite (20%)

    1-10% (LGS or DS)

    Irritability, agitation (5-9%)

    Anger, aggression (3-5%)

    Decreased weight (3-5%)

    Hypoxia, respiratory failure (3%)

    Infection, fungal (1-3%)

    1-10% (TSC)

    Gait disturbance (9%)

    Ear infection (8%)

    Decreased weight (7%)

    Decreased platelet count (5%)

    Increased eosinophil count (5%)

    Fatigue, malaise, asthenia (5%)

    Urinary tract infection (5%)

    Warnings

    Contraindications

    Hypersensitivity to cannabidiol or any of the product ingredients

    Cautions

    Can cause somnolence and sedation that is dose-related; clobazam and other CNS depressants, including alcohol, may potentiate this adverse effect; monitor for somnolence and sedation and advise patients not to drive or operate machinery until they have gained sufficient experience on drug to gauge whether it adversely affects their ability to safely drive or operate machinery

    Antiepileptic drugs (AEDs), including cannabidiol, increase risk of suicidal thoughts or behavior in patients taking these drugs for any indication; patients should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, or any unusual changes in mood or behavior

    May cause hypersensitivity reactions (eg, pruritus, erythema, angioedema)

    As with other AEDs, cannabidiol should generally be withdrawn gradually because of the risk of increased seizure frequency and status epilepticus; if withdrawal is needed because of a serious adverse event, rapid discontinuation can be considered

    Therapy can cause weight loss, which may be dose-related

    A decrease in hemoglobin and hematocrit reported with no effect on red blood indices

    Elevation of serum creatinine reported within 2 weeks of initiating therapy that was reversible in healthy adults; mechanism not determined

    Medscape – Seizure dosing for Epidiolex (cannabidiol), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

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    Comments

    The person you need to be

    The person you need to be discussing this with is your neurologist. Mant people think that MJ can help a person with issues they have. Other people think it will get them high. Doctors will know dosages and can help a person get those set. Too much can be as harmful as too little when it comes to medications. MJ can be different so I won’t go into that. Contact your neurologist. Understand that he will need to know if you are doing this so if you have a seizure he can look at th ammount along with your regular AED in order to set dosage levels.

    We work with physicians in

    We work with physicians in Brazil who manage children with epilepsy. If you are still seeking direction, please email me – [email protected]

    I would love some assistance

    I would love some assistance as well. [email protected] Thank you

    I would also appreciate some

    I would also appreciate some assistance. [email protected] Thank u

    Hi guys, am Kelvin. My

    Hi guys, am Kelvin. My daughter Yaya would turn 5yr by July. When she was a little over 3yr she came back from school and started convulsing. And that was the first time ever she convulsed. And she was treated at the hospital for malaria because she was diagnosed of one but later it kept coming monthly and later daily. We saw a specialist and had CT scan and EEG and both didn’t find anything. To cut long story short, no drug was able to minimize the attack and now she is blind for a year now, can walk, talk, reason. still wear s diapers .I am just hearing of epidiolex which I can’t afford but I have been reading about cannabis oil. So I have decided to do a homemade one but I need the dosage and advice on what else I should do or not do if I begin the cannabis oil for her. [email protected] That is my email address. Pls I need help

    DON’T IGNORE THIS, SOME ONE

    DON’T IGNORE THIS, SOME ONE YOU KNOW MIGHT NEED IT PLEASE.A great testimony I must share to all cancer patients in the world. My husband was diagnosed with stage 4 primary liver cancer in March 2014, doctor told us there was not much to be done since the tumor was 7 inches covering his lower lobe and also had spread to his lymph nodes, We decided to go home and called hospice which gave us morphine for pain, Ed hated the morphine which made him vomit and also affected his mind. After one week at home we decided to do what we have done for many years, rely on ourselves. We were only in Hospital for 3 days with severe Pain, the cancer had blocked his bile duct, after that we choose a Naturalist doctor and have not had conventional treatments.One day i came across the use of cannabis oil for treatment of cancer and i saw a post on how a cancer patient was cured with cannabis oil. I urgently needed help and i contacted the email :([email protected]) to get the cannabis oil, i was given instructional guide on how to use it. After taking a gram of oil per day, Within a couple of weeks his pain and swollen stomach disappeared and with it came hope and a good quality of life,we did it withoutundergoing surgery or and other physical medical pains.We never saw an oncologist and only have done a blood test after the first diagnose CT scan. His tumor marker went from over6000 to normal and he is feeling well. We don’t know how this is going to play out, but enjoy every day and give thanks to God. As i am writing this post, my husband is free from liver cancer and the doctor confirmed that the cancer is gone. For immediate assistance on every medical issue you and your family may be experiencing, contact Dr Rick via email: ([email protected]) for more information and the delivery process.This cannabis oil have healed over 5000 people with different types and stages of cancer.

    Hi! My name is Uldis, my son

    Hi! My name is Uldis, my son Robbie has generalized epilepsy! We is 1y9m old! He still doesnt walk or talk! We use depkine syrup! I have read a lot about CBD oil and have bouth it online! It is 2,5%! I have no idea with what amounts should I start, and should I!? I have absoluttely no one to talk about it here, becouse noone(even doctors) know anything about it, as well as about the epilepsy its self( so it seems)!

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