Cannabis Therapy for Dystonia [Does It Work?]
Dystonia is a general term that doctors use to describe a group of movement disorders. These conditions involve uncontrollable muscle spasms and sometimes pain. They can have a massive impact on the sufferer’s quality of life, but treatment options are limited.
With medical marijuana and CBD becoming more popular, some patients are wondering whether cannabis therapy can help dystonia. We investigate in this in-depth article. But, first, let’s take a closer look at dystonia and its symptoms.
What Is Dystonia?
The term ‘dystonia’ describes any one of several conditions that affect the muscles and movement. It results in uncontrollable muscle spasms and cramps, which can be extremely painful.
There are many different subtypes of dystonia, each affecting a different part of the body. They include the following:
- Generalized dystonia (affects the whole body)
- Myoclonus dystonia (affects the arms, torso, and neck)
- Cervical dystonia (only affects the neck)
- Blepharospasm (affects the eyes)
- Laryngeal dystonia (affects the larynx)
- Oromandibular dystonia (affects the lower face, jaw, and tongue)
Some types of dystonia are ‘task-specific,’ meaning that they only occur when carrying out certain activities. These activities might include writing, typing, or playing a musical instrument.
In the early stages, dystonia symptoms are often mild. They may only occur in an isolated body part when performing a specific activity.
Eventually, these symptoms may progress to other body parts and become present most of the time. However, this is not always the case. Some people find that their dystonia either plateaus or improves over time.
The most common symptoms of dystonia include:
- Unusual twisting of the affected body part
- Slow, repetitive movements
- Muscle spasms and cramping
- Uncontrollable blinking
Dystonia symptoms can occur for the first time at any age. Most types of dystonia are more common in women than in men.
What Causes Dystonia?
Most experts agree that dystonia results from an abnormality in one of the brain regions responsible for movement.
For example, the basal ganglia control voluntary muscle and eye movements, among other things. This region of the brain is often dysfunctional in patients with dystonia, although other areas may also be involved.
Dystonia also appears to have a link with certain neurotransmitters, such as dopamine and gamma-aminobutyric acid (GABA). When the brain is unable to process these neurotransmitters effectively, their messages can become jumbled, leading to abnormal movement.
Doctors generally classify dystonia into one of three categories:
- Idiopathic dystonia: This type of dystonia has no apparent cause.
- Genetic dystonia: Mutations in a specific gene cause a variety of dystonia that runs in families.
- Acquired dystonia: A kind of dystonia that occurs due to brain injury (stroke, oxygen deprivation, or physical trauma) as well as certain medications.
Dystonia often appears in tandem with other medical conditions, including Parkinson’s disease, multiple sclerosis, and cerebral palsy. Moreover, there are several dystonia triggers that can exacerbate symptoms. These include:
- Activities such as talking, chewing, writing, typing, etc.
Common Dystonia Treatments (Not Cannabis)
Unfortunately, there is no cure for dystonia yet. However, there are several treatments that may help patients to manage their symptoms:
- Botulinum toxin (Botox) injections
- Muscle relaxants
- Physical or occupational therapy
- Deep brain stimulation
Deep brain stimulation involves placing a battery in the chest or abdomen. It is connected to the brain via thin wires and provides electrical stimulation to specific areas of the brain. For some patients, it can give as much as 50% relief from symptoms. However, others derive minimal benefit.
With dystonia treatment options so limited, it is little wonder that some patients are turning to cannabis. But does it really help?
Does Cannabis Help Dystonia?
Cannabis therapy has become widely accepted in recent years. The majority of American states now have medical marijuana programs in place, and some even allow recreational use.
Furthermore, new research is continually shedding light on the myriad benefits of the plant. To date, most studies have focused on THC and CBD, the two most prominent cannabinoids. THC is probably best known for its intoxicating effects but also possesses a wealth of medicinal uses. On the other hand, CBD is famous for providing many similar benefits to THC but without the high.
So far, research into cannabis for dystonia has yielded somewhat mixed results. According to a 2015 study for the journal Neurotherapeutics, there have been several reports of marijuana helping patients with dystonia. However, these are mostly single case reports, and large-scale clinical trials are lacking.
One 2002 study assessed the effects of nabilone (a synthetic form of THC) for dystonia. It found that there were no significant improvements in the majority of its subjects. However, three of the 15 participants reported feeling better for several days after treatment.
Research into CBD for dystonia is slightly more promising. A 2002 study for the European Journal of Pharmacology tested CBD on hamsters with idiopathic dystonia. They found that high doses delayed the progression of the disease.
Another study for The International Journal of Neuroscience followed five patients with dystonic movement disorders. The participants took CBD doses between 100mg and 600mg daily for a total of six weeks.
Amazingly, all of the patients experienced improvements, ranging between 20% and 50%. However, two patients with Parkinson’s features found that doses over 300mg exacerbated their symptoms.
CBD Effects on Dystonia
The most likely explanation for CBD’s effects on dystonia is its interaction with the endocannabinoid system (ECS). This system is present in most of the body’s tissues, including the brain.
The ECS is composed of cell receptors called cannabinoid receptors (CB1 and CB2) and chemicals called endocannabinoids. These two components bind together like a lock and key to regulate a range of physiological functions. The ECS is involved in mood, appetite, and immunity, among other things.
The ECS also plays a crucial role in motor function. There is an exceptionally high concentration of CB1 and CB2 receptors in the basal ganglia of the brain. Experts have hypothesized that this is where CBD exerts its effects on dystonia.
CBD works by slowing the breakdown of endocannabinoids, thus increasing their levels in the brain. This has a direct influence over the release of neurotransmitters like dopamine and GABA.
Furthermore, CBD has potent antioxidant and anti-inflammatory effects. These benefits mean that it could help to protect structures in the brain from damage in conditions like Parkinson’s disease.
Although more research is necessary to confirm how well CBD works for dystonia, the initial findings are encouraging. So, what do you need to know before you try it?
What Is the Best CBD for Dystonia?
If you decide to try CBD for dystonia, there are a few things to bear in mind.
If you live somewhere where medical marijuana is legal and have a qualifying condition, you can apply for an MMJ card. This card will allow you to purchase high-CBD cannabis strains or CBD oil from licensed dispensaries.
The advantage of this is that you can choose a product containing some THC alongside its CBD and benefit from both cannabinoids.
However, if you live somewhere without a medical marijuana program, you will be limited to buying hemp-derived CBD oil. This product contains just trace amounts of THC and is, therefore, legal in the majority of places.
Hemp-derived CBD is also an excellent option for anyone who does not want to deal with the intoxicating effects of THC.
The problem with many CBD products is that the market is not well-regulated. Therefore, a lot of companies are selling items that are not up to scratch. Some contain far less CBD than they should, while others could include contaminants like pesticides or solvents.
Therefore, you should be cautious when buying CBD oil for dystonia. Look for a brand that offers third-party lab reports on its website. These reports tell you exactly what is in each product and prove there is nothing to hide.
You will also find a huge variety of different CBD products to choose from, and picking one can be confusing. For more guidance on purchasing CBD, check out our article: What CBD Therapy is Best for You?
Cannabis Therapy for Dystonia: Final Thoughts
Dystonia is a condition which has a severe impact on a person’s quality of life. It can cause not only severe pain but also makes everyday activities a challenge. Furthermore, there are few truly effective treatments available.
Therefore, many people are turning to cannabis therapy for dystonia. There have been many reports over the years of this natural medicine relieving dystonia symptoms. However, hard clinical evidence is lacking, so there is no guarantee that it will work for everyone.
If you are thinking about trying cannabis or CBD oil for dystonia, consult a medical professional first. They will ensure that it is safe for you and offer additional advice on how to manage your symptoms.
We investigate whether cannabis and CBD oil can help to relieve the symptoms of dystonia. Here's everything you need to know.
Cannabinoids and Dystonia
Dystonia is a neurological movement disorder syndrome in which involuntary repetitive muscle contractions and spasms result in abnormal fixed postures or twisting. It can affect only one muscle, a group of muscles or even the entire body. It is believed to affect 1 % of the world’s population and it has been found to be more prevalent in women. In general, the cause is unknown. However, what is known is that it is often related to a problem with the basal ganglia (the area of the brain in control of initiating muscle contractions). It has also been found to be a sign of other illnesses such as Parkinson’s and Wilson’s disease.
Symptoms often associated with Dystonia
- Cramping in the foot/ feet
- Speech difficulties
- Uncontrollable blinking
- Involuntary pulling of the neck
- A “dragging leg”
Muscle fatigue and stress from constant spontaneous movements can be one of the things that prompt the other symptoms to become worse. Strong pain killers (like opioids) and muscle relaxers provides some relief. Pain experienced can vary from nothing to severe, all depending on the personal tolerance and/or the source of the problem. In addition, current treatments focus on blocking nerve communications with the muscles. Unfortunately, all prescriptions come with negative side effects and possible addiction and dependency.
Research about medical cannabis and dystonia
After extensive research it has been found that Cannabidiol (CBD) is one safe alternative, due to its powerful analgesic mechanism, extremely low risk for addiction and virtually no adverse effects. Thus, CBD has anti-inflammatory, anxiolytic, antioxidant and neuroprotective properties, among others.
Another disease that disrupts signals between the brain and the rest of the body is Multiple Sclerosis (MS). CBD has been shown to improve some symptoms in this neurological problem, such as decreases muscle spasms.
Literature continues to include more case reports and surveys of CBD´s benefits. According to a case reported, a patient with dystonia secondary to Wilson’s disease, obtained marked improvement in response to the inhalation of Cannabis. Another published paper review found that the use of Cannabidiol showed a dose-response relationship, in order to see changes in dystonia.
Although studies in this area are difficult to do, there is a clear role for cannabis products in symptom management for this neurologic condition.
A review of the research done into the use of cannabinoids as therapy for Dystonia, a neurological movement disorder syndrome.